Neuroanatomical Substrates For Introspective Accuracy Of Memory

Metacognition of a tactile working memory task has been demonstrated by researchers at Aalto University and the University of Helsinki, for the first time. Understanding this brain function might help in the development of new treatments for neuropsychiatric illnesses in the future.

By combining neural pathway imaging and magnetic stimulation of the brain targeting the prefrontal cortex, the researchers were able to improve a test subject’s ability to evaluate his or her performance in a tactile working memory task.

The ability of human subjects to monitor and control their own cognitive processes is called metacognition. Metacognition is important for people and in many neuropsychiatric illnesses, it is possible to recognize that it has weakened.

Transcranial Magnetic Stimulation

Doctoral Candidate Juha Gogulski said:

“The patient’s reduced sense of being ill is familiar from conditions such as Alzheimer’s disease, schizophrenia, and traumatic brain injury. Understanding the brain function of healthy test subjects could help in the development of new treatment methods for neuropsychiatric illnesses in the future.”

Transcranial magnetic stimulation refers to a method in which the nerve cells of the brain are activated from outside the skull with the help of a magnetic field. When used correctly the method is safe, and it is utilized in procedures such as pinpointing the location of the primary motor cortex or the speech area before brain surgery, and in the treatment of depression.

neural substrate metacognition

Determination of TMS targets on the PFC.
Credit: Juha Gogulski, et al. Oxford University Press

Taking part in the study as test subjects were 14 healthy volunteers.

They first underwent structural magnetic resonance imaging (MRI) of the brain as well as a diffusion MRI that is sensitive to the movement of water molecules in the brain, making it possible to identify the direction of neural pathways. After the MRI, the neural pathway connections between the primary somatosensory cortex and the prefrontal cortex were determined for each individual.

Introspective Accuracy Of Memory

In the last part of the study the test subjects completed working memory tasks in which they were asked to keep in mind the characteristics of touch sensations from the fingertip and to evaluate whether or not the touch stimulation that was just given was similar to or different from the previous stimulus. During the test they were given magnetic pulses to prefrontal cortex areas that had a neural pathway connection to the part of the somatosensory cortex representing the index finger.

The test subjects also evaluated how certain they were about their answers, on which basis calculations were made on how well a person’s own evaluation corresponded to the actual performance level.

Magnetic stimulation of the prefrontal cortex improved the test subjects’ evaluation of their performance, as they were able to assess more accurately if their answers had been correct or incorrect.

Funding for the study was provided by the Sigrid Jusélius Foundation, the Academy of Finland, Instrumentarium Science Foundation and Finnish Cultural Foundation.

Juha Gogulski, Rasmus Zetter, Mikko Nyrhinen, Antti Pertovaara, Synnöve Carlson
Neural Substrate for Metacognitive Accuracy of Tactile Working Memory
Cerebral Cortex, https://doi.org/10.1093/cercor/bhx219

Image: Spooky Pooka, Wellcome Images