Stress May Be As Harmful To Your Body As Junk Food Diet

Stress could be just as unhealthy for you as a really bad diet, a new Brigham Young University study finds.

Laura Bridgewater, BYU professor of microbiology and molecular biology, exposed female lab mice to stress, and found their gut microbiota — the microorganisms vital to digestive and metabolic health — were altered to appear as though the mice had been eating a high-fat diet.

“Stress can be harmful in a lot of ways, but this research is novel in that it ties stress to female-specific changes in the gut microbiota. We sometimes think of stress as a purely psychological phenomenon, but it causes distinct physical changes,”

Bridgewater said.

Stress And Gender Differences

Bridgewater and her collaborators at Shanghai Jiao Tong University in China took a large group of 8-week-old mice and exposed half of the males and half of the females to a high-fat diet. After 16 weeks, all of the mice were exposed to mild stress over the course of 18 days.

Researchers then extracted microbial DNA from the mice fecal pellets before and after the stress to test how the gut microbiota was affected. They also measured mouse anxiety based on how much and where the mice traveled in an open field arena.

The researchers found fascinating differences between gender.

Male mice on the high-fat diet exhibited more anxiety than females on the high-fat diet, and high-fat males also showed decreased activity in response to stress. However, it was only in female mice that stress caused the gut microbiota composition to shift as if the animals were on a high-fat diet.

While the study was only carried out on animals, researchers believe there are could be significant implications for humans.

“In society, women tend to have higher rates of depression and anxiety, which are linked to stress. This study suggests that a possible source of the gender discrepancy may be the different ways gut microbiota responds to stress in males vs. females,”

noted Bridgewater, who serves as Associate Dean of the BYU College of Life Sciences.

The research was supported by the National Natural Science Foundation of China and the Science and Technology Commission of Shanghai Municipality.

Laura C. Bridgewater, Chenhong Zhang, Yanqiu Wu, Weiwei Hu, Qianpeng Zhang, Jing Wang, Shengtian Li & Liping Zhao
Gender-based differences in host behavior and gut microbiota composition in response to high fat diet and stress in a mouse model
Scientific Reports 7, Article number: 10776 (2017) doi:10.1038/s41598-017-11069-4