Does the mere site of someone drawing blood make you wince with imagined pain? Fear not. Researchers at the University of North Carolina have developed a way to create hollow ceramic needles so fine that patients would not feel them piercing their skin. This new polymerization technology could some day take the pain out of injections and blood draws. Clustered together on a patch, these microneedles can deliver drugs or draw blood efficiently as standard hypodermic needles.
Reported in the International Journal of Applied Ceramic Technology Jan. 2008 issue , the two-photon polymerization technique is similar to the technology used in stereo-lithography rapid prototyping, which is basically a 3-dimensional laser printer. In two-photon polymerization (2PP), near-infrared (IR) laser pulses are directed at photosensitive materials to form layers of structure.
Painless Glucose Monitoring?
Ã¢â‚¬Å“Microneedles may be integrated with micropumps and biosensors to provide autonomous sampling of blood, analysis, and drug-delivery capabilities for treatment of chronic disease,Ã¢â‚¬Â said Roger Narayan, MD, PhD and lead researcher on the project. Ã¢â‚¬Å“For example, one needle, pump and sensor unit would assay the glucose level in interstitial fluid of patients with diabetes mellitus. Another needle, pump and drug-delivery unit would deliver insulin in a continuous or programmed manner.Ã¢â‚¬Â
Creating methods to intravenously deliver drugs with minimal pain and trauma, preferably by someone without specialized medical training, has been a longtime dream of biomedical engineers.  Until recently, their most promising product had been stainless steel and titanium microneedles . These metal microneedles, though, are prone to break on impact with skin.
Using organically modified ceramic hybrid materials, these new microneedles are resistant to breakage. How many other potential uses for these can you come up with? I can think of a few, but they involve espionage, biowarfare and terrorism, not such good news.