Desperate for relief, parents are taking unusual steps to help children plagued with seizures. The relief, however, comes in a most unlikely form: marijuana.
As many as 30 percent of people with epilepsy— or about one million Americans— still have seizures while on Food and Drug Administration (FDA)-approved treatments. It’s left many who suffer from uncontrollable seizures, or their parents, since many are children—turning to medical marijuana and its derivatives in an attempt to take back control of a disease with no cure.
A seizure is an abnormal electrical storm in the brain that causes sudden alteration in consciousness, sensation, and behavior that can manifest in a variety of ways, from an eye flicker to full-body convulsions. People with medication-resistant (also called intractable) epilepsy suffer from consequences of recurrent seizures, which could damage the brain and adversely impact their quality of life.
Stories about desperate parents seeking anything to relieve their children’s seizures abound, but how much scientific evidence is there for cannabis’ effectiveness? Says D. Samba Reddy, professor in the neuroscience and experimental therapeutics department at Texas A&M University and author of a new study published in the Journal of Pharmacology and Experimental Therapeutics:
“There was a lot of media attention about how medical marijuana is good for epilepsy. We became interested in finding out whether there was scientific evidence in the literature to support the claims of these people who have seen great benefits.”
Conducting Trials Not Easy
There are at least 85 active components of the plant colloquially known as marijuana, but two major ones of have been the focus of study: delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD).
THC is the psychoactive component of the plant, while CBD doesn’t cause any sort of a “high” and isn’t thought to be addictive. Preliminary studies—largely in animal models—have shown CBD might have some anti-seizure potential.
Derivatives of marijuana high in CBD (but with negligible amount of THC) might offer some benefit for intractable epilepsy. CBD-enriched products, like Epidiolex and Realm Oil, exist, but their efficacy hasn’t been proven and they exist in a sort of legal grey area.
Homemade compounds exist, but since they don’t go through rigorous best practice manufacturing procedures and haven’t been approved by the FDA, it can be difficult for consumers to know exactly what they’re getting.
Although THC is known to share the actions of anandamide (from the Indian Sanskrit word “anand” for bliss or happiness), a naturally occurring compound in the brain, the exact mode of anti-seizure action of CBD is unclear.
“It is critical to know how CBD controls seizures, so pharmaceutical companies can design novel synthetic compounds for epilepsy that could surpass the hurdles of mixed CBD extracts,” says Reddy, who directs an epilepsy research lab at Texas A&M.
These compounds might provide the benefits without some of the risks—or the legal issues—associated with the marijuana plant.
A standard manufacturing process and clinical trials might help answer some of these questions, but conducting one isn’t easy, and there are currently only 19 clinical trials going on to test the use of cannabinoids for epilepsy. For one thing, cannabis is still listed as a Schedule I substance by the federal government, meaning gaining permission to use it in research on human participants is extremely difficult.
Still, change is occurring at the state level.
Recreational marijuana use is legal for adults in four states (Alaska, Colorado, Oregon, and Washington) and in 23 states and Washington, DC, medical marijuana is allowed. Texas, in a law passed during the last legislative session in 2015, legalized low-THC cannabis oils for people with intractable epilepsy while still prohibiting medical marijuana more broadly.
A new study at the University of Colorado Anschutz Medical Campus is enrolling Dravet epilepsy patients who have tried Charlotte’s Web, a specific strain of medical marijuana that is low in THC and high in CBD. The researchers will compare the genetics of those who have seen seizure activity decreased dramatically (at least 50 percent) in response to the drug versus those who did not.
Although this research could yield useful information about how CBD and genetic factors interact in a Dravet population, it is not the gold standard of scientific drug trials: the randomized, placebo-controlled, double-blinded clinical trial in which patients were randomly assigned to either CBD or a placebo.
For now, most experts are taking a cautious wait-and-see approach.
The American Epilepsy Society (AES) has released a statement on the use of medical marijuana in the treatment of epilepsy stating that due to the lack of data, no conclusion can be drawn at present. The Epilepsy Foundation doesn’t specifically discourage cannabis use, but urges anyone exploring treatment for epilepsy to work with their treating physician to make the best decisions for their own care and to follow applicable laws.
“Despite all of the controversy about medical marijuana as a potential therapy for epilepsy,” Reddy says, “most people agree that what we need is greater rigorous scientific study into cannabinoids to prove or disprove their safety and efficacy.”
Doodipala Samba Reddy and Victoria Golub
The Pharmacological Basis of Cannabis Therapy for Epilepsy
JPET January 19, 2016 jpet.115.230151