Magnesium Helps Regulate Cellular Timekeeping And Energy Balance

An essential mineral in our diets has a surprising role in helping living things remain adapted to the rhythms of night and day, scientists have found.

Magnesium, a nutrient found in many foods, helps control how cells keep their own form of time to cope with the natural environmental cycle of day and night.

The discovery in cells is expected to be linked to whole body clocks which influence daily cycles, known as circadian rhythms, of sleeping and waking, hormone release, body temperature and other important bodily functions in people.

The surprising discovery may aid the development of chronotherapy, treatment scheduled according to time of day, in people, and the development of new crop varieties with increased yields or adjustable harvesting seasons.

Daily Magnesium Cycles

Experiments in three major types of biological organisms – human cells, algae, and fungi – found in each case that levels of magnesium in cells rise and fall in a daily cycle.

Scientists found that this oscillation was critical to sustain the 24-hour clock in cells. They were surprised to discover that it also had an enormous impact on metabolism in cells – how fast cells can convert nutrients into energy – throughout the course of a day.

Researchers at the University of Edinburgh and the MRC Laboratory for Molecular Biology in Cambridge used molecular analysis to find that concentrations of magnesium rose and fell in a 24-hour cycle in all cell types, and that this impacts on the cells’ internal clocks.

Further tests showed that magnesium levels were linked to the cells’ ability to burn energy. It was already known that magnesium is essential to help living things convert food into fuel, but scientists were surprised to discover that it also controls when this biological function takes place, and how efficiently.

Fundamental to all Living Things

Dr Gerben van Ooijen, of the University of Edinburgh’s School of Biological Sciences, who led the study, said:

“Internal clocks are fundamental to all living things. They influence many aspects of health and disease in our own bodies, but equally in crop plants and micro-organisms. It is now essential to find out how these fundamentally novel observations translate to whole tissue or organisms, to make us better equipped to influence them in complex organisms for future medical and agricultural purposes.”

The study’s other senior author, Dr John O’Neill of the MRC Laboratory of Molecular Biology in Cambridge, said:

“Although the clinical relevance of magnesium in various tissues is beginning to garner more attention, how magnesium regulates our body’s internal clock and metabolism has simply not been considered before. The new discovery could lead to a whole range of benefits spanning human health to agricultural productivity.”

Kevin A. Feeney, Louise L. Hansen, Marrit Putker, Consuelo Olivares-Yañez, Jason Day, Lorna J. Eades, Luis F. Larrondo, Nathaniel P. Hoyle, John S. O’Neill & Gerben van Ooijen
Daily magnesium fluxes regulate cellular timekeeping and energy balance
Nature (2016) doi:10.1038/nature17407

Image: Joshua Nordberg, Christopher English, and the 2004 Olympus BioScapes Digital Imaging Competition. Fluorescence micrograph of a human epithelial cell in mitosis, labeled for alpha tubulin (blue), gamma tubulin (green) and DNA (red). The image was taken with a 100x objective and processed with deconvolution.