Overlooked MRI Signal May Aid Diagnosis Of Brain Conditions

A new technique that analyzes overlooked data from MRI scans reveals how many and which brain cells patients have — and shows where they’ve lost cells through injury or disease.

The method eventually may lead to new ways to diagnose Alzheimer’s disease, multiple sclerosis, traumatic brain injury, autism, and other brain conditions through a simple brain scan.

“There’s no easy way to detect the loss of neurons in living people, but such loss plays a role in many neurological diseases. We’ve shown in the past that there’s a signal that goes down in parts of the brain in people with Alzheimer’s disease, multiple sclerosis, and traumatic brain injury, but we didn’t know what it meant. Now, we know it means neurons have died in those areas,”

says Dmitriy Yablonskiy, professor of radiology at the Mallinckrodt Institute of Radiology at Washington University in St. Louis.

The Other Part Of The Ocean

Most researchers studying brain function with MRI are only interested in a small portion of the MRI signal. They want to see how the MRI signal changes when a person performs a task, not what stays the same.

Researchers trying to understand vision, for example, focus on the signal variation due to the brain activity when a person looks at a picture, and discard the parts of the signal that hold steady. But that’s like looking at the waves along the surface of the ocean, and ignoring the mass of water beneath.

For the new study researchers decided to find what the rest of the ocean could tell us about how the brain works.

They analyzed the background data on an MRI scan and found a signal, which they called decay rate parameter (R2t*), that remained largely unchanged when people performed tasks but varied across parts of the brain. Then, they compared the R2t* signal with data from the Allen Human Brain Atlas, which maps genes active in various areas of the brain.

Brain Change Clues

The researchers found three sets of gene networks that tracked with the R2t* signal — the genes were more active where the signal was strong, and less active where the signal was weak. These groups of genes, it turned out, reflected the different kinds and numbers of brain cells, and the extent of connections between them.

In other words, this quick new MRI scan gave the researchers all they needed to know to determine how densely packed and interconnected the neurons are in any part of the brain. This information could clarify how a person’s brain develops and changes from infancy to old age, and how we build memories and learn. It could also give clues to brain illness or injury.

“We did some studies on traumatic brain injury where we found some areas of the brain are already losing neurons even though the standard scans show nothing,”

Yablonskiy says.

The researchers also applied their technique to the hippocampus — the memory center of the brain — in people with Alzheimer’s disease. They found that not only was the hippocampus smaller than in healthy people, but the remaining part was not healthy—it had lost cells and begun to decay.

“There are MRI scans now that can detect brain atrophy even before people show symptoms of Alzheimer’s disease. Our technique can show the brain degrading even before it begins to atrophy,”

Yablonskiy says.

Six Minute Scans

The researchers are now working on applying their technique to brain diseases and disorders including Alzheimer’s, schizophrenia, multiple sclerosis, and autism, as well as to understanding how a healthy brain develops and grows.

“We’ve developed a method that takes a six-minute scan and tells you what types of cells are there and how extensively they’re connected. As babies develop, neurons start growing, they connect with each other, they start forming memories. Nobody really knows how this is done. But this method could help us understand normal development, as well as how brain diseases develop,”

Yablonskiy says.

The National Institute of Health supported the work.

Jie Wen, Manu S. Goyal, Serguei V. Astafiev, Marcus E. Raichle, Dmitriy A. Yablonskiy
Genetically defined cellular correlates of the baseline brain MRI signal
Proceedings of the National Academy of Sciences Sep 2018, 201808121; DOI: 10.1073/pnas.1808121115

Image: Windell Oskay/Flickr