Eating Stimulates Endogenous Opioid Release In The Brain

The way in which eating stimulates brain’s endogenous opioid system to signal pleasure and satiety has been uncovered by researchers from University of Turku in Finland.

Results of a study show that eating leads to widespread opioid release in the brain, likely signalling feelings of satiety and pleasure.

Eating a delicious pizza led to significant increase of pleasant feelings, whereas consumption of calorie-matched nutritional drink did not. However, both types of meals induced significant release of endogenous opioids in the brain.

Opioids are associated with pleasure and euphoria. The study revealed that a significant amount of endorphins is released in the entire brain after eating the pizza and, surprisingly, even more are released after the consumption of the tasteless nutritional drink.

The magnitude of the opioid release was independent of the pleasure associated with eating. According to the researchers, it is likely that the endogenous opioid system regulates both feelings of pleasure and satiety.

Overstimulated Opioid System

Professor Lauri Nummenmaa from Turku PET Centre said:

“The opioid system regulates eating and appetite, and we have previously found that its dysfunctions are a hallmark of morbid obesity. The present results suggest that overeating may continuously overstimulate the opioid system, thus directly contributing to development of obesity. These findings open new opportunities for treating overeating and the development of obesity.”

The study was done using positron emission tomography (PET). The participants were injected with a radioactive compound binding to their brain’s opioid receptors.

Radioactivity in the brain was measured three times with the PET camera: after a palatable meal (pizza), after a non-palatable meal (liquid meal) and after an overnight fast.

“It was a surprise that endorphins are released in the entire brain and that the nutritional drink had a larger impact. This creates a basis for future research and hopefully we will find ways to study and describe the development and predictors of addiction, obesity and eating disorders”,

said researcher, Jetro Tuulari M.D., PhD.

Jetro J. Tuulari, Lauri Tuominen, Femke E. de Boer, Jussi Hirvonen, Semi Helin, Pirjo Nuutila and Lauri Nummenmaa
Feeding Releases Endogenous Opioids in Humans
Journal of Neuroscience 23 August 2017, 37 (34) 8284-8291; DOI: https://doi.org/10.1523/JNEUROSCI.0976-17.2017

Image: Turku PET Centre

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