So how effective are weight-loss drugs? And are they worth the cost?
Last week, we published a study on the cost effectiveness of weight-loss drugs in the international science journal PLOS One. It was part of our NHMRC-funded ACE Prevention study, which examined the cost effectiveness of 150 public health interventions in Australia.
An earlier 2008 systematic review found most published studies reported anti-obesity medications were cost effective. So we were initially optimistic our review would uncover similar findings.
Prescription Weight Loss Medications
The most commonly prescribed drugs to aid weight loss are sibutramine and orlistat.
Orlistat (Xenical) is a lipase inhibitor which appears to aid weight loss by preventing the digestion and absorption of dietary fat.
Both were available in Australia and subsidised under the Pharmaceutical Benefits Schedule (PBS) until late last year, when sibutramine was withdrawn due to safety concerns.
In our study, we assumed obese patients would take orlistat or sibutramine as directed, for a period of 12 months. But trials have shown that about half the participants using sibutramine and one third of orlistat users had stopped before the end of the year.
This may have been because they experienced some common side effects, such as increased blood pressure for sibutramine and abdominal complaints for orlistat.
On average, people who started taking sibutramine lost 4.5 kg from the drug alone. For orlistat the average weight loss was 2.9 kg. But this wasn’t sustained.
The little available evidence shows that once people stopped taking the drugs, they quickly regained the weight they had lost. After about a year, they were likely to be at their original weight.
(Interestingly, the weight lost through diet and exercise interventions also came back but around four times slower, as participants gradually reverted to their old habits.)
Prescription medicines can reduce weight by 4.5kg but not for long. Ben Werdmuller von Elgg
One year of treatment with either drug costs around $1,475. Quite an expense for just a few kilograms of weight loss over a short period of time.
But in assessing the cost effectiveness of a medicine, we need consider how the benefits of person’s weight loss will reduce the cost of their health care later in life.
On average, every “healthy life year” gained with sibutramine cost about $140,000. This means a large number of people need to be treated with the drug before it adds up to gains that equal one year of good health. Orlistat allows “buying” healthy life years at a net price of around $240,000 each.
Health interventions that cost less than $50,000 are usually considered good value for money. Statin drugs, which lower cholesterol, for instance, cost around $25,000 per healthy life year and diuretics (used to reduce blood pressure) cost around $2,000 per healthy life year.
Using this cost-effectiveness threshold, neither obesity drug seems to be a very good buy. Further, they only reduce the rates of obesity-related disease – such as type 2 diabetes, heart disease and osteoarthritis – by a small percentage.
Our results aren’t in line with most previous studies, which concluded both drugs offer good value for money.
Several factors may have contributed to this discrepancy, including incorrect assumptions that:
Everybody would continue taking their medication.
The weight would come back over three or five years (not one year, as the evidence shows)
23% of the weight reduction was permanent (for which we found no evidence).
Another consideration is that 11 out of the previous 14 studies were paid for by the pharmaceutical company that marketed the particular drug.
The few independently funded studies found much less favourable results, with an average of €62,000 (A$82,000) per healthy life year for independent studies, compared with €15,000 (A$20,000) for industry-sponsored studies.
Cost-effectiveness analysis is a process in which many decisions add up to rather opaque models. You can achieve almost any result you want by tweaking the assumptions. So studies funded by parties with vested interests ought to be treated with caution.
It’s important to note that side-effects of drugs may only become evident after some time. Sibutramine is a case in point: it was taken off the market last year because trials showed it increased the risk of heart attack and stroke.
So it’s clear that current obesity drugs aren’t the silver bullets that will halt or reverse the obesity epidemic.
Well-designed diet and exercise interventions are less expensive and more effective than current pharmacotherapy. But the best bet for lasting weight loss is to change our “obesogenic” environment, through limiting the availability and advertising of unhealthy foods.
This is the ninth part of our series The science behind weight loss. To read the other instalments, follow the links below: