Brain-implanted Chip Restores Sensation In Paralyzed Man

Scientists have, for the first time, help restore the sense of touch to a paralyzed man.

A decade ago, 28-year-old Nathan Copeland was involved in an automobile accident that left him unable to feel any sensation in his arms and fingers. Now, through a mind-controlled robotic arm that is directly connected to his brain, has regained that sensation, with the help of a team of scientists at the University of Pittsburgh Medical Center.

The team of experts was led by Robert Gaunt, Ph.D., assistant professor of physical medicine and rehabilitation at University of Pittsburgh.

In the winter of 2004, Nathan, who lives in western Pennsylvania, was driving at night in rainy weather when he was in a car accident that snapped his neck and injured his spinal cord, leaving him with quadriplegia from the upper chest down, unable to feel or move his lower arms and legs, and needing assistance with all his daily activities. He was 18 and in his freshman year of college pursuing a degree in nanofabrication, following a high school spent in advanced science courses.

He tried to continue his studies, but health problems forced him to put his degree on hold. He kept busy by going to concerts and volunteering for the Pittsburgh Japanese Culture Society, a nonprofit that holds conventions around the Japanese cartoon art of anime, something Mr. Copeland became interested in after his accident.

microarray

Courtesy of UPMC/Pitt Health Sciences

Right after the accident he had enrolled himself on Pitt’s registry of patients willing to participate in clinical trials. Nearly a decade later, the Pitt research team asked if he was interested in participating in the experimental study.

Mind-controlled Robotics

Study co-author Andrew B. Schwartz, Ph.D., distinguished professor of neurobiology and chair in systems neuroscience, Pitt School of Medicine, and a member of the University of Pittsburgh Brain Institute, says:

“The most important result in this study is that microstimulation of sensory cortex can elicit natural sensation instead of tingling. This stimulation is safe, and the evoked sensations are stable over months. There is still a lot of research that needs to be carried out to better understand the stimulation patterns needed to help patients make better movements.”

After he passed the screening tests, Nathan was wheeled into the operating room last spring. Study co-investigator and UPMC neurosurgeon Elizabeth Tyler-Kabara, M.D., Ph.D., assistant professor, Department of Neurological Surgery, Pitt School of Medicine, implanted four tiny microelectrode arrays each about half the size of a shirt button in Nathan’s brain. Prior to the surgery, imaging techniques were used to identify the exact regions in Mr. Copeland’s brain corresponding to feelings in each of his fingers and his palm.

This is not the Pitt-UPMC team’s first attempt at a brain computer interface (BCI). Four years ago, study co-author Jennifer Collinger, Ph.D., assistant professor, Pitt’s Department of Physical Medicine and Rehabilitation, and research scientist for the VA Pittsburgh Healthcare System, and the team demonstrated a BCI that helped Jan Scheuermann, who has quadriplegia caused by a degenerative disease.

The video of Scheuermann feeding herself chocolate using the mind-controlled robotic arm was seen around the world. Before that, Tim Hemmes, paralyzed in a motorcycle accident, reached out to touch hands with his girlfriend.

Of course, the miracle of being able to move our arms naturally move and interact with the environment around us is due to more than just thinking and moving the right muscles. We are able to differentiate between a piece of cake and a soda can through touch, picking up the cake more gently than the can.

Constant Feedback Required

The constant feedback we receive from the sense of touch is of paramount importance as it tells the brain where to move and by how much.

For Dr. Gaunt and the rest of the research team, that was the next step for the BCI. As they were looking for the right candidate, they developed and refined their system such that inputs from the robotic arm are transmitted through a microelectrode array implanted in the brain where the neurons that control hand movement and touch are located. T

The microelectrode array and its control system, which were developed by Blackrock Microsystems, along with the robotic arm, which was built by Johns Hopkins University’s Applied Physics Lab, formed all the pieces of the puzzle.

“I can feel just about every finger—it’s a really weird sensation,” Mr. Copeland said about a month after surgery. “Sometimes it feels electrical and sometimes its pressure, but for the most part, I can tell most of the fingers with definite precision. It feels like my fingers are getting touched or pushed.”

At this time, Mr. Copeland can feel pressure and distinguish its intensity to some extent, though he cannot identify whether a substance is hot or cold, explains Dr. Tyler-Kabara.

Michael Boninger, M.D., professor of physical medicine and rehabilitation at Pitt, and senior medical director of post-acute care for the Health Services Division of UPMC, recounted how the Pitt team has achieved milestone after milestone, from a basic understanding of how the brain processes sensory and motor signals to applying it in patients

“Slowly but surely, we have been moving this research forward. Four years ago we demonstrated control of movement. Now Dr. Gaunt and his team took what we learned in our tests with Tim and Jan—for whom we have deep gratitude—and showed us how to make the robotic arm allow its user to feel through Nathan’s dedicated work,”

said Dr. Boninger, also a co-author on the research paper.

Dr. Gaunt explained that everything about the work is meant to make use of the brain’s natural, existing abilities to give people back what was lost but not forgotten.

“The ultimate goal is to create a system which moves and feels just like a natural arm would,” says Dr. Gaunt. “We have a long way to go to get there, but this is a great start.”

Sharlene N. Flesher, Jennifer L. Collinger, Stephen T. Foldes, Jeffrey M. Weiss, John E. Downey, Elizabeth C. Tyler-Kabara, Sliman J. Bensmaia, Andrew B. Schwartz, Michael L. Boninger, Robert A. Gaunt
Intracortical microstimulation of human somatosensory cortex
Science Translational Medicine 19 Oct 2016: DOI: 10.1126/scitranslmed.aaf8083

Top Image: Courtesy of UPMC/Pitt Health Sciences