Bile acid sequestrants such as cholestyramine, colestipol, and colesevelam attach themselves to the bile acids in the intestine that contain cholesterol. The body then can get rid of the cholesterol in bowel movements rather than absorbing it.
These drugs, even in small doses, can lower LDL cholesterol a moderate amount – by up to 20% in many patients. Since these drugs lower cholesterol only a modest amount, they are often combined with satins for more effective treatment of high cholesterol.
If you take these drugs to lower your cholesterol, you must take them with water or fruit juice and with food. If you take other medication, you will have to be careful to take those medications one hour before or several hours after the acid bile sequestrants, as these cholesterol-lowering medications may affect how other drugs are absorbed by your body. Your doctor will have to advise you when to take your other medications to ensure that these cholesterol medications do not affect your treatment of other health conditions.
Usually, bile acid sequestrates are prescribed in doses meant to be taken once or twice a day. If you take these cholesterol-lowering medications, you need to drink plenty of water, as many patients experience unpleasant symptoms such as gas, nausea, constipation, and feeling of bloating when taking bile acid sequestrants