Meta-analyses Links Antidepressant Use With Increased Risk Of Mortality

Antidepressant medications increase the risk of death and cardiovascular events, new research from a McMaster university-led team of researchers finds.

It is well known that brain serotonin affects mood, and that most commonly used antidepressant treatments for depression block the re-absorption of serotonin by neurons. It is less widely recognized, however, that all the major organs of the body — including the heart, kidneys, lungs, liver — use serotonin from the bloodstream.

SSRI antidepressants block the absorption of serotonin in these organs as well. The researchers caution that antidepressants could increase the risk of death by preventing multiple organs from functioning properly.

Death, Strokes And Heart Attacks

Researchers conducted a meta-analysis of studies involving hundreds of thousands of people. They found that antidepressant users had a 33% higher chance of death than non-users.

Antidepressant users also had a 14% higher risk of cardiovascular events, such as strokes and heart attacks.

“We are very concerned by these results. They suggest that we shouldn’t be taking antidepressant drugs without understanding precisely how they interact with the body,”

says co-author Paul Andrews, associate professor at McMaster University who led the research team.

Taken by one in eight adult Americans, antidepressants are among the most frequently used medications. They are often prescribed by family doctors without a formal diagnosis of depression, on the assumption they are safe.

Since depression itself can be deadly — people with clinical depression are at an increased risk of suicide, stroke and heart attack — many physicians think that antidepressants could save lives by reducing depressive symptoms.

Assumptions Undermined

However, McMaster researcher and co-author Marta Maslej, says,

“Our findings are important because they undermine this assumption. I think people would be much less willing to take these drugs if they were aware how little is known about their impact outside of the brain, and that what we do know points to an increased risk of death.”

Benoit Mulsant, a psychiatrist at the University of Toronto who was also involved in the study, says the findings point to the need for more research on how antidepressants actually do work.

“I prescribe antidepressants even though I do not know if they are more harmful than helpful in the long-term. I am worried that in some patients they could be, and psychiatrists in 50 years will wonder why we did not do more to find out,”

Mulsant says.

The news about antidepressants is not all bad.

The researchers found that antidepressants are not harmful for people with cardiovascular diseases such as heart disease and diabetes. This makes sense since these antidepressants have blood-thinning effects that are useful in treating such disorders.

Unfortunately, this also means that for most people who are in otherwise good cardiovascular health, antidepressants tend to be harmful.

Maslej M.M., Bolker B.M., Russell M.J., Eaton K., Durisko Z, Hollon S.D.,  Swanson G.M, Thomson Jr. J.A., Mulsant B.H., Andrews P.W.
The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis
Psychother Psychosom 2017;86:268-282 https://doi.org/10.1159/000477940

Image: Steve Snodgrass/Flickr

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