Does Aluminum Cause Alzheimer’s And Breast Cancer?

Silvery, ductile, malleable and so very, very useful, aluminum is the most common metal in the Earth’s crust. But despite its importance (or perhaps because of it), there are fears that this metal causes everything from cancer to Alzheimer’s disease.

From aircraft to tableware, aluminum forms an important and ubiquitous part of our lives. It’s so common now, in fact, that it’s difficult to believe that, at one stage, metallic aluminum was so hard to make that having aluminum plates was a symbol of wealth.

But as it has become more commonplace, aluminum’s safety profile has come into question, with particular emphasis on aluminum in antiperspirants. The evidence for its supposed harms is weak, if not non-existent.

Yes, aluminum can be toxic, but in the spirit of my blog’s patron, remember it’s the dose that makes the poison.

The metal’s toxic effects can be seen in people working at aluminum smelters or those who have had similar industrial exposures with inadequate workplace safety measures. People on dialysis who have been exposed to higher than normal aluminum levels in their dialysis fluid also show a range of adverse effects, including damage to the brain and the nervous system.

And you can show neurotoxic effects in animals at lower (but still substantial) concentrations, if you inject aluminum directly into the brain. But the vast majority of us will never be exposed to such high concentrations of aluminum as in these cases. Our exposures will come from drinking water, food, antacid tablets and rubbing antiperspirant with aluminum on our skin.

The aluminum we’re exposed to in these ways is in the form of aluminum salts. These salts are surprisingly hard to get into the body; only 0.1% of ingested aluminum is absorbed into the body.

Skin absorption is also quite weak and skin absorption of aluminum from antiperspirants contributes to less than 3% of blood levels of aluminum (the rest comes from gut absorption). So you need to go to some effort to get toxic levels of aluminum from these sources.

Indeed, according to the results of long-term animal studies you need to consume around 10,000 times the amount of aluminum in our water supplies to see the beginnings of neurotoxicity. Even if you were chewing antacids every day while rubbing antiperspirants all over yourself, you would still not have enough aluminum in your system to suffer from neurotoxicity.

So, while animal studies are all very well, is there any evidence from humans that our modest consumption of aluminum over long periods of time is toxic?

Alzheimer’s Disease

Beta amyloid

Beta amyloid Ian Musgrave via Jmol

A common misconception about aluminum is that it causes Alzheimer’s disease. And since a large chunk of my research is on finding treatments for Alzheimer’s disease, I have a bit of insight into such claims.

Some very early studies suggested that there was more aluminum in the brains of people with Alzheimer’s disease than those without. Almost immediately, people selling stainless steel cookware seized on this result to promote their pots over aluminum ones (we were buying new cookware at this time, and I had some interesting discussions with these people).

Aluminum is rather hard to measure at the low levels that are in the brain, and later studies with better methods failed to find elevated aluminum levels in the brains of people with Alzheimer’s. Actually, there’s good evidence the positive results were due to contamination.

Personally, I wouldn’t have been surprised to find increased aluminum in the brains of Alzheimer’s sufferers. There’s an accumulation of a toxic protein called beta amyloid in the brains of people with Alzheimer’s disease. This protein binds metals including aluminum, but it binds copper, zinc and iron more strongly. In part, this binding of copper and zinc contributes to the protein’s toxicity. Despite significant amounts of copper in the accumulated amyloid in the brains of people with Alzheimer’s however, there’s no evidence that high levels of copper exposure increase the disease’s incidence.

What’s more, people on dialysis who are exposed to much higher concentrations of aluminum than most people for long periods of time don’t have a higher incidence of Alzheimer’s disease than people not on dialysis.

So, aluminum and Alzheimer’s disease, no.

Breast Cancer

In breast cancer, the upper outer quadrant of the breast is more likely to be the site where tumors first appear than anywhere else. Since this quadrant is closest to the lymphatic drainage from the armpit, people have leapt to the conclusion that aluminum from application of antiperspirants is the culprit.

But the incidence of tumors is directly related to the amount of breast tissue, and that quadrant happens to have the most breast tissue.

Epidemiological data is rather sparse, but what little there is makes the aluminum-breast cancer link unlikely. A 2002 study found no correlation between aluminum containing antiperspirant use and breast cancer. A more recent meta-analysis found few high-quality studies, but those they found showed no evidence of an antiperspirant link to breast cancer.

So, aluminum and breast cancer, highly unlikely.

Alzheimer’s disease and breast cancer are devastating to both those who develop the diseases and their families. Everyone involved wants to know why these diseases strike. These are complex diseases, with complex and still poorly understood causes, but we can be pretty certain that the aluminum in antiperspirants is not one of those causes.The Conversation

Author: Ian Musgrave, Senior lecturer in Pharmacology, University of Adelaide

This article was originally published on The Conversation.

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