Accelerated Aging Linked To Post-traumatic Stress Disorder

People suffering from post-traumatic stress disorder may also be at risk for accelerated aging or premature senescence, according to researchers at University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System.

Health concerns about post-traumatic stress disorder (PTSD) have risen significantly recently, driven in part by affected military veterans returning from conflicts in the Middle East and elsewhere. PTSD is associated with number of psychological maladies, among them chronic depression, anger, insomnia, eating disorders and substance abuse.

Senior author Dilip V. Jeste, MD, director of the Center on Healthy Aging and Senior Care at UC San Diego, said:

“This is the first study of its type to link PTSD, a psychological disorder with no established genetic basis, which is caused by external, traumatic stress, with long-term, systemic effects on a basic biological process such as aging.”

Researchers had previously seen a potential association between psychiatric conditions, such as schizophrenia and bipolar disorder, and acceleration of the aging process.

Reduced Telomere Length

Jeste and his team wanted to see if PTSD might show a similar association by conducting a comprehensive review of published empirical studies relevant to early aging in PTSD, covering multiple databases going back to 2000.

There is no standardized definition of what constitutes premature or accelerated senescence.

For guidance, the researchers looked at early aging phenomena associated with non-psychiatric conditions, such as Hutchinson-Gilford progeria syndrome, HIV infection and Down’s syndrome. The majority of evidence fell into three categories:

  • biological indicators or biomarkers, such as leukocyte telomere length (LTL)
  • earlier occurrence or higher prevalence of medical conditions associated with advanced age
  • premature mortality

In their literature review, the UC San Diego team identified 64 relevant studies; 22 were suitable for calculating overall effect sizes for biomarkers, 10 for mortality.

All six studies looking specifically at LTL found reduced telomere length in persons with PTSD. Leukocytes are white blood cells.

Telomeres are stretches of protective, repetitive nucleotide sequences at the ends of chromosomes. These sequences shorten with every cell replication and are considered a strong measure of the aging process in cells.

Imflammation

The scientists also found consistent evidence of increased pro-inflammatory markers, such as C-reactive protein and tumor necrosis factor alpha, associated with PTSD.

A majority of reviewed studies found increased medical comorbidity of PTSD with several targeted conditions associated with normal aging, including cardiovascular disease, type 2 diabetes, gastrointestinal ulcer disease and dementia.

Seven of 10 studies indicated a mild-to-moderate association of PTSD with earlier mortality, consistent with an early onset or acceleration of aging in PTSD.

“These findings do not speak to whether accelerated aging is specific to PTSD, but they do argue the need to re-conceptualize PTSD as something more than a mental illness,” said first author James B. Lohr, MD, professor of psychiatry. “Early senescence, increased medical morbidity and premature mortality in PTSD have implications in health care beyond simply treating PTSD symptoms. Our findings warrant a deeper look at this phenomenon and a more integrated medical-psychiatric approach to their care.”

Barton Palmer, PhD, professor of psychiatry and a coauthor of the study, cautioned:

“Prospective longitudinal studies are needed to directly demonstrate accelerated aging in PTSD and to establish underlying mechanisms.”

Reference:

Johanna E. Gerwer, Colin Depp, Dilip V. Jester
Do Mental Health Diagnoses and Treatment Predict Advance Directive Completion in Older Adults? A Population Based Study
The American Journal of Geriatric Psychiatry, Vol. 23, Issue 3, S124–S125

James B. Lohr, Barton W. Palmer, Carolyn A. Eidt, Smitha Aailaboyina, Brent T. Mausbach, Owen M. Wolkowitz, Steven R. Thorp, Dilip V. Jeste
Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature
The American Journal of Geriatric Psychiatry, DOI: http://dx.doi.org/10.1016/j.jagp.2015.04.001