Delusional Misidentification Syndrome Brain Lesions Mapped

Delusional misidentification syndrome (DMS), is a group of rare disorders that leaves patients convinced people and places aren’t really as they seem.

Now, neuroscientists at Beth Israel Deaconess Medical Center (BIDMC) have mapped the brain injuries – or lesions – that result in the symdromes. Michael D. Fox, MD, PhD, Director of the Laboratory for Brain Network Imaging and Modulation and colleagues have identified the neuro-anatomy underlying these syndromes for the first time.

Delusional misidentification syndromes are among the most striking and least understood disorders encountered in neurology and psychiatry.

First documented nearly a century ago, Capgras syndrome is a rare disorder in which patients recognize a family member while simultaneously experiencing that person as unfamiliar, leading to the conclusion that an imposter is impersonating their loved one.

Conversely, the Fregoli delusion is the belief that strangers are actually loved ones in disguise. Misidentification delusions can also apply to pets and places.

Brain Connectivity Disruption

Fox, also the Associate Director of the Berenson-Allen Center for Noninvasive Brain Stimulation at BIDMC, said:

“How the brain generates complex symptoms like this has long been a mystery. We showed how complex symptoms can emerge based on brain connectivity.

With a lesion in exactly the right place, you can disrupt the brain’s familiarity detector and reality monitor simultaneously, resulting in bizarre delusions. Understanding where these symptoms come from is an important step toward treating them.”

Fox and colleagues, including lead author R. Ryan Darby, MD, in a study published in the journal Brain, identified 17 patients with delusional misidentification syndromes and mapped them onto a standardized brain atlas.

Then, using the lesion network mapping technique they recently developed, Darby and colleagues determined that all 17 lesions were functionally connected to an area of the brain called the retrosplenial cortex – thought to be involved in perceiving familiarity.

Sixteen of the 17 lesions were also connected to a region in the right ventral frontal cortex, associated with belief evaluation. The scientists compared the data to 15 control brain injuries that led to delusions other than misidentification delusions.

Familiarity And Belief Violation

Darby, the Sidney R. Baer, Jr. Foundational Fellow in the Clinical Neurosciences at the Berenson-Allen Center at BIDMC, said:

“Lesions causing all types of delusions were connected to belief violation regions, suggesting that these regions are involved in monitoring for delusional beliefs in general. However, only lesions causing delusional misidentifications were connected to familiarity regions, explaining the specific bizarre content – abnormal feelings of familiarity – in these delusions. In other words, lesions had to be connected to both regions to develop delusions like Capgras.”

The scientists note that their network mapping technique does not involve obtaining functional neuroimaging (fMRI) from the patients studied. Rather, data from normal patients determines which regions of the brain are normally connected to the mapped lesion locations.

While this methodology carries several advantages, it does not prove these two regions are dysfunctional in delusional patients following the lesion. Doing so would require recruiting a large number of patients with the rare disorder to a follow up study, noted Darby.

However, the new information gleaned from their study may help patients’ families cope with a loved one’s misidentification delusions—which sometimes disappear as mysteriously as they come on.

“The impact on the patient’s family can be heart-breaking,” said Darby. “I’ve seen patients who, thinking their homes were replicas, would pack their bags every night, hoping to return to their ‘real’ home. Patients who believe a spouse is an imposter often lose intimacy. In these cases, even just knowing that the delusion has a name and is part of a neurological disorder can be helpful for family members.”

Darby R, Prasad S.
Lesion-Related Delusional Misidentification Syndromes: A Comprehensive Review of Reported Cases
J Neuropsychiatry Clin Neurosci. 2016 Feb 22:appineuropsych15100376

Image: Wellcome Images

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