Common Antioxidant May Protect Against Nonalcoholic Fatty Liver Disease

Pyrroloquinoline quinone, a common antioxidant found in human breast milk and foods like kiwi fruit can protect against nonalcoholic fatty liver disease (NAFLD) in the offspring of obese mice, according to researchers at the University of Colorado Anschutz Medical Campus.

Their study is the first to demonstrate that pyrroloquinoline quinone can protect offspring of obese mothers from acceleration of obesity induced liver disease.

Lead author Karen Jonscher, PhD, an associate professor of anesthesiology and a physicist at CU Anschutz, said:

“Pyrroloquinoline quinone, or PQQ, is a natural antioxidant found in soil and many foods and enriched in human breast milk. When given to obese mouse mothers during pregnancy and lactation, we found it protected their offspring from developing symptoms of liver fat and damage that leads to NAFLD in early adulthood.”

Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease is the most common liver disease in the world, affecting 20-30 percent of all adults in the U.S. and over 60 percent of those who are obese. It heightens the risk of cardiovascular disease, type 2 diabetes and liver cancer.

Scientists have found that mice fed a high fat, Western-style diet give birth to offspring with a higher chance of getting the disease.

“We know that infants born to mothers with obesity have a greater chance of developing NAFLD over their lifetime, and in fact one-third of obese children under 18 may have undiagnosed fatty liver disease that, when discovered, is more likely to be advanced at the time of diagnosis,” Jonscher said.

“The goal of our study, which we carried out using a mouse model of obese pregnancy, was to determine whether a novel antioxidant given to mothers during pregnancy and breastfeeding could prevent the development of NAFLD in the offspring.”

Jonscher and her colleagues fed adult mice healthy diets or Western-style diets heavy on fat, sugar and cholesterol. They gave a subset of both groups PQQ in their drinking water.

Their offspring were kept on the diets for 20 weeks. Those fed a Western diet gained more weight than those on a healthy diet. PQQ did not change the weight gain but it did reduce the fat in the livers even before the mice were born.

Pyrroloquinoline Quinone

The antioxidant also reduced inflammation in the livers of mice fed the Western diet. The researchers found that pyrroloquinoline quinone protected adult mice from fatty liver, even when it was stopped after three weeks when the mice quit breastfeeding.

Jonscher believes the antioxidant may work by impacting pathways critical to the early onset of diseases associated with maternal obesity, high fat diets and inflammation.

PQQ is found in human breast milk, soy, parsley, celery, kiwi and papaya. It’s also found in soil and even in interstellar dust.

Jonscher said it could possibly be used as a prenatal or lactation supplement to protect children of obese mothers from developing liver and cardiovascular disease in adulthood, but cautioned that pregnant women should always consult their doctor before taking any supplement.

K. R. Jonscher, M. S. Stewart, A. Alfonso-Garcia, B. C. DeFelice, X. X. Wang, Y. Luo, M. Levi, M. J. R. Heerwagen, R. C. Janssen, B. A. de la Houssaye, E. Wiitala, G. Florey, R. L. Jonscher, E. O. Potma, O. Fiehn, J. E. Friedman
Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice
The FASEB Journal, 2016; DOI: 10.1096/fj.201600906R

Image: Muffet / liz west CC BY 2.0

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